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Extra caution is important with: Frequent vomiting or suspected cannabinoid hyperemesis Symptoms of gastroparesis, including early fullness, nausea, vomiting, bloating, and upper abdominal pain Diabetes medications that can cause low blood sugar, including insulin or sulfonylureas Heavy cannabis use, high THC products, or unpredictable edibles dosing Prior dehydration, severe constipation, pancreatitis, or unexplained severe abdominal pain Very low appetite, unintended weight loss, or eating disorder history Multiple sedating substances Upcoming surgery, anesthesia, endoscopy, colonoscopy, or gastric emptying testing GLP-1 medications can delay gastric emptying, which also matters for procedures and anesthesia planning

These measures are critical to maintaining the required temperature range of 36F to 46F (2C to 8C) throughout preparation and shipping

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Every few months, the two would reach various small goals, aiming for lower insulin levels, better cholesterol and better sleep

The mechanisms underlying the impact of PM on the respiratory system involve oxidative stress, mitochondrial damage, inflammation of airway epithelial cells, cell damage, extracellular matrix remodeling, and fibrosis [7]

CONFLICT OF INTEREST The authors declare that they have no competing interests